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Erosive Esophagitis and Accompanying GERD Symptoms: 20 mg daily for 4-8 weeks.
Maintenance Healing of Erosive Esophagitis: 20 mg daily.
Children: GERD: Dose Range: 0.7-1.4 mg/kg body weight daily up to a maximum daily dose of 40 mg for 4-12 weeks.
Gastric and Duodenal Ulcer: 20 mg single daily dose orally or 40 mg in severe cases is given. Treatment is continued for 4 weeks for duodenal ulcer and 8 weeks for gastric ulcer. When appropriate, a dose of 10-20 mg once daily may be given for maintenance.
NSAID-Associated Ulceration: A dose of 20 mg daily, which may also be used for prophylaxis in patients with a previous history of gastroduodenal lesions who require continued NSAID treatment.
Helicobacter pylori Eradication: 40 mg daily may be combined with antibacterials in dual therapy or 20 mg twice daily may be combined with antibacterials in triple therapy. Omeprazole alone may be continued for a further 2-8 weeks.
Zollinger-Ellison Syndrome: Initial Recommended Dose: 60 mg orally once daily, adjusted as required. The majority of patients are effectively controlled by doses in the range of 20-120 mg daily, but doses of up to 120 mg 3 times daily have been used. Daily doses >80 mg should be administered in divided doses.
Dyspepsia: Usual Dose: 10 or 20 mg daily orally for 2-4 weeks.
Prophylaxis of Acid Aspiration: Also used for the prophylaxis of acid aspiration during general anesthesia in a dose of 40 mg in the evening before surgery and a further 40 mg 2-6 hrs before the procedure.
Hepatic Impairment: Maximum Daily Dose: 20 mg is recommended for patients with impaired hepatic function.
Vial: GERD, Peptic Ulcer Disease, Treatment and Prophylaxis of NSAID-Associated Ulceration: 40 mg IV once daily.
Zollinger-Ellison Syndrome: Initial Dose: 60 mg IV daily. Higher daily doses may be required and the dose should be adjusted individually. Doses >60 mg should be given twice daily.
Prophylaxis of Acid Aspiration: 40 mg IV to be completed 1 hr before surgery.
Hepatic Impairment: 10-20 mg daily may be sufficient or as directed by a physician.
Risek Insta: Recommended dosing given in the following table. (See table.)
Click on icon to see table/diagram/imageSince both 20 mg and 40 mg oral suspension sachets contain the same amount of sodium bicarbonate (1680 mg), 2 sachets of Risek Insta 20 mg are not equivalent to 1 sachet of Risek Insta 40 mg; therefore two 20 mg sachets should not be substituted for 1 sachet Risek Insta 40 mg.
Administration: Risek: Capsule: Risek is given orally which should be swallowed whole and not crushed or chewed.
IV: Risek vial should be given as an IV infusion (over a period of 20-30 min). The contents of 1 vial must be dissolved in at least 100 mL of normal saline or 100 mL of 5% dextrose in IV chamber.
Preparation: With a syringe, draw 5 mL of infusion solution from the infusion bag. Add the infusion solution to the lyophilized powder of omeprazole in the vial. Mix thoroughly, making sure all the powder is dissolved. Draw the omeprazole solution back into the syringe. Transfer the solution into the infusion bag. Repeat the previous steps to make sure all the powder is transferred from the vial into the infusion bag.
Riske Insta: Risek Insta should be taken on an empty stomach at least 1 hr before a meal.
Direction for Reconstitution: Empty the sachet contents into a small cup containing 15-30 mL (1-2 tbsp) of water to form suspension. Stir well and drink immediately. Refill cup with water and drink. Do not use other liquids or food.
